Traditionally, Epistemology has presumed that the task of analysing human knowledge, in view of the fact that it was a philosophical task, could be carried out in an a priori way, but it will be mediated by conceptual, logical or transcendental analysis, without the need, however, to repeat the results of the empirical investigation.Quine (1969), defended the thesis that this way of proceeding was erroneous and that epistemology should be naturalized. Such naturalization meant that epistemology should abandon the speculative and a priori procedures that had characterized it and become part of the empirical sciences.This book aims to introduce the reader to the problems of the origin and evolution of scientific knowledge. This work is the result of my academic experience, which has been enriched by the results of my research and by the contributions of my fellow researchers who have enriched the content of this book, with the aim of contributing to the philosophical debate on Epistemology, as a current generator of scientific knowledge or theory of knowledge.