Two possibilities should be considered for the origin of SARS-CoV-2: natural evolution or laboratory creation. In this groundbreaking scientific book, we disprove the possibility of SARS-CoV-2 arising naturally through evolution, and instead prove that SARS-CoV-2 must have been a product of laboratory modification in China. We use in-depth analyses of the available data and literature to prove that these novel animal Coronaviruses do not exist in nature and their sequences have been fabricated. In addition, we also offer our insights on the hypothesis that SARS-CoV-2 may have originated naturally from a Coronavirus that infected the Mojiang miners.